Excess growth hormone (GH) is associated with which condition?

Excess growth hormone (GH) is primarily associated with acromegaly, a condition that arises due to overproduction of GH, usually from a benign tumor of the pituitary gland known as an adenoma. Acromegaly typically manifests in adulthood and is characterized by the gradual enlargement of bones and tissues, particularly noticeable in the face, hands, and feet. This increase in GH leads to heightened levels of insulin-like growth factor 1 (IGF-1), which promotes the growth of various tissues in the body.

In acromegaly, patients may also experience various systemic effects, such as metabolic changes, cardiovascular complications, and increased risk for certain types of cancer due to prolonged exposure to elevated GH levels. The condition can significantly impact quality of life and often requires medical intervention, including surgery or medication to reduce GH production.

The other conditions listed, like hypoparathyroidism, Cushing syndrome, and Addison's disease, each involve different hormonal imbalances or deficiencies and do not correlate with the overproduction of growth hormone. Thus, acromegaly is the clear association with excess growth hormone.