When hormonal alterations are prolonged, which of the following may result?

When hormonal alterations are prolonged, increased hunger can result due to the impact of hormones like insulin, ghrelin, and leptin on appetite regulation. For instance, insulin, which is responsible for glucose metabolism, can affect hunger levels. If there are prolonged alterations in insulin levels, such as those seen in insulin resistance, it can lead to changes in how the body signals hunger and satiety, often resulting in increased feelings of hunger.

Similarly, ghrelin, known as the "hunger hormone," may increase in response to prolonged stress or hormonal imbalances, leading to an overall increase in appetite. Conversely, leptin, the hormone that promotes fullness, may become less effective due to chronic hormonal changes, further exacerbating feelings of hunger. Therefore, prolonged hormonal disruptions can contribute to sustained increased hunger, highlighting the interconnectedness of hormonal balance and appetite regulation.