Which of the following factors is considered a risk factor for impaired glucose regulation?

Corticosteroid use is recognized as a significant risk factor for impaired glucose regulation due to its impact on insulin sensitivity and glucose metabolism. These medications, commonly prescribed for inflammatory conditions, can raise blood glucose levels by stimulating gluconeogenesis (the production of glucose from non-carbohydrate sources) and decreasing peripheral glucose uptake. As a result, individuals using corticosteroids may exhibit impaired insulin action, leading to hyperglycemia and an increased risk for developing conditions like insulin resistance or type 2 diabetes.

In contrast, maintaining a healthy weight, engaging in regular moderate exercise, and hydration through high water intake generally promote better glucose regulation and overall metabolic health. These factors are often associated with improved insulin sensitivity and lower blood glucose levels, making them protective rather than risk factors in the context of glucose regulation.